SALBUTAMOL

 

Salbutamol 

NAME:- Salbutamol

IUPAC NAME:- 

(RS)-4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol

USES:-

1) Its used to treat Asthma
2) Its used to treat COPD ( Chronic Obstructive Pulmonary Disease)
3) It relaxes the muscles of airways of lungs that make it easy
    to  breathe.

MECHANISM OF ACTION:

The Salbutamol acts on Beta2 adrenergic receptor which are present in 
Bronchial smooth muscles and relaxes it. 

STRUCTURE :-     

ADVERSE DRUG REACTION:-

1) Muscle pain and muscle cramps.
2) Dizziness
3) Shivering
4) Headache
5) Abnormal heartbeat-Very fast or very slow.
6) Chest Pain

SYNTHESIS:-

1) In start  P-hydroxybenzaldehyde and paraformaldehyde both react and form Stage-I compound.

2) Stage-I compound is reacted with water to give compound-II

3) Two hydroxyl under H2SO4 catalyst is protected by propylidine.
4)Compound (4) is obtained under ylide reagent and phase transfer catalyst effect.
5) Compound (4) undergoes reflux in tert-butyl amine to carry out aminolysis ring
 opening reaction and to get compound (5).
6) Hydrolysis of compound (5) in acidic conditions gives Salbutamol.

WHO INVENTED:-

David Jack (1966)

REFERENCE:- NA